Abstract | OBJECTIVE: METHODS: We measured serum KL-6 levels in 184 patients with IIM using a chemiluminescent enzyme immunoassay and compared KL-6 levels between patients with and without ILD, according to other clinical features. RESULTS: IIM patients with ILD had significantly higher serum KL-6 levels than those without ILD (776.5 [372.3-1378.8] vs. 297.5 [204.75-599.3] U/ml, P < 0.001). At a cut-off of 461.5 U/ml identified by ROC curve, serum KL-6 yielded a sensitivity of 70.2% and specificity of 73.9% for ILD in IIM patients. IIM patients with an elevated serum KL-6 were more likely to have clinical symptoms of mechanic's hands (P = 0.002), anti-Jo-1 antibody positivity (P = 0.021), dysphagia (P = 0.039), hoarseness (P < 0.001), and polyarthritis/ polyarthralgia (P < 0.001). Significant inverse correlations were found between serum KL-6 levels and pulmonary function tests (P < 0.01), including forced vital capacity (FVC, % Pred), total lung capacity (TLC, % Pred), and diffusing capacity for carbon monoxide (DLCO, % Pred). CONCLUSIONS: Serum KL-6 offers high sensitivity and specificity for the diagnosis of IIM-associated ILD and is inversely correlated with pulmonary function deterioration. Serum KL-6 may represent a promising biomarker for monitoring ILD severity in IIM patients.
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Authors | Chaojun Hu, Chanyuan Wu, Enhao Yang, Hui Huang, Dong Xu, Yong Hou, Jiuliang Zhao, Mengtao Li, Zuojun Xu, Xiaofeng Zeng, Qian Wang |
Journal | Clinical rheumatology
(Clin Rheumatol)
Vol. 38
Issue 8
Pg. 2181-2187
(Aug 2019)
ISSN: 1434-9949 [Electronic] Germany |
PMID | 30888566
(Publication Type: Journal Article)
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Chemical References |
- MUC1 protein, human
- Mucin-1
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Topics |
- Adult
- China
- Cross-Sectional Studies
- Dermatomyositis
(blood, complications)
- Female
- Humans
- Immunoenzyme Techniques
- Lung Diseases, Interstitial
(blood, complications)
- Male
- Middle Aged
- Mucin-1
(blood)
- Polymyositis
(blood, complications)
- ROC Curve
- Respiratory Function Tests
- Sensitivity and Specificity
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