Influence of nonsynaptic α1 glycine receptors on ethanol consumption and place preference.

Abstract

Here, we used knock-in (KI) mice that have ethanol-insensitive alpha 1 glycine receptors (GlyRs) (KK385/386AA) to examine how alpha 1 GlyRs might affect binge drinking and conditioned place preference. Data show that tonic alpha 1 GlyR-mediated currents were exclusively sensitive to ethanol only in wild-type mice. Behavioral studies showed that the KI mice have a higher intake of ethanol upon first exposure to drinking and greater conditioned place preference to ethanol. This study suggests that nonsynaptic alpha 1-containing GlyRs have a role in motivational and early reinforcing effects of ethanol.

• Authors: Braulio Muñoz, Scarlet Gallegos, Christian Peters, Pablo Murath, David M Lovinger, Gregg E Homanics, Luis G Aguayo
• Journal: Addiction biology (Addict Biol) Vol. 25 Issue 2 Pg. e12726 (03 2020) ISSN: 1369-1600 [Electronic] United States
• PMID: 30884072 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 Society for the Study of Addiction.

Chemical References

• Receptors, Glycine
• Ethanol

Topics

• Alcoholism (metabolism, physiopathology)
• Animals
• Brain (drug effects, metabolism, physiopathology)
• Disease Models, Animal
• Ethanol (metabolism, pharmacology)
• Mice
• Mice, Inbred C57BL
• Receptors, Glycine (drug effects, metabolism)