Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis.

Abstract

BACKGROUND:

Sucrose allyl ether (SAE) containing hemostatic drugs and a photoinitiator was established to treat mild postpartum hemorrhage or long-term continuous abnormal uterine bleeding in minimally invasive surgery (MIS) using a photopolymerization method.

METHODS AND RESULTS:

Real-time infrared spectroscopy and rheological experiments showed that the SAE monomer with shear-thinning characteristics could polymerize rapidly into a transparent membrane. Cytotoxicity experiments in vitro showed that this system could elicit a long-term hemostatic effect. Tissue adhesion was also evaluated. The photo-stability of four delivered antifibrinolytic drugs (6-aminocaproic acid, ethylenediaminediacetic acid, tranexamic acid and p-(aminomethyl) benzoic acid) was tested by ultraviolet-photolysis experiments and illustrated by time-dependent density functional theory. Sustained-release experiments revealed that the formed film could be used as a drug carrier. Molecular docking and molecular dynamics were done to investigate the binding mechanism between hemostatic drugs as ligands and the human plasminogen kringle-1 (1HPK) as a target.

CONCLUSION:

It has been suggested that SAE with tranexamic acid could be a drug-release system of microchannel transport used in MIS. This system could tackle the dilemma of fluidity and adhesion in MIS. The photo-stable tranexamic acid was the most suitable drug according to its satisfactory binding energy, good photo-stability, and sustained release.

• Authors: Hong Huang, Houhe Liu, Hua Zhou, Zhiling Liang, Dandan Song, Yun Zhang, Wanqiu Huang, Xiaotian Zhao, Bo Wu, Guodong Ye, Yugang Huang
• Journal: Drug design, development and therapy (Drug Des Devel Ther) Vol. 13 Pg. 881-896 ( 2019) ISSN: 1177-8881 [Electronic] New Zealand
• PMID: 30880920 (Publication Type: Journal Article)

Chemical References

• Antifibrinolytic Agents
• Drug Carriers
• Ligands
• Plasminogen

Topics

• Antifibrinolytic Agents (pharmacology)
• Density Functional Theory
• Drug Carriers (chemistry)
• Drug Liberation
• Hemostasis
• Humans
• Kringles (drug effects)
• Ligands
• Minimally Invasive Surgical Procedures
• Models, Molecular
• Plasminogen (drug effects)
• Time Factors