Infant Psychosocial Environment Predicts Adolescent Cardiometabolic Risk: A Prospective Study.

Abstract

OBJECTIVE:

To prospectively assess whether the infant psychosocial environment was associated with cardiometabolic risk as early as adolescence.

STUDY DESIGN:

Participants were recruited in Santiago, Chile, and have been followed from infancy. Inclusion criteria included healthy infants with birth weight ≥3 kg and a stable caregiver. The psychosocial environment, including depressive symptoms, stressful life events, poor support for child development, father absence, and socioeconomic status, was reported by mothers at 6-12 months. Body mass index (BMI) z score was assessed at 5 and 10 years. BMI z score, waist-to-hip ratio, systolic and diastolic blood pressure, fat mass and body fat percentage, fasting glucose, total and high-density lipoprotein cholesterol, and homeostatic model of insulin resistance were tested in adolescence.

RESULTS:

Adolescents ranged from 16 to 18 years of age (n = 588; 48.1% female). A poorer infant psychosocial environment was associated with BMI z score at 10 years (β = 0.10, 95% CI = 0.00-0.19) and in adolescence (β = 0.15, 95% CI = 0.06-0.24) but not at 5 years. A poorer infant psychosocial environment was associated with higher blood pressure (β = 0.15, 95% CI = 0.05-0.24), greater anthropometric risk (β = 0.13, 95% CI = 0.03-0.22), greater biomarker (triglycerides, homeostatic model assessment of insulin resistance, total cholesterol) risk (β = 0.12, 95% CI = 0.02-0.22), and a higher likelihood of metabolic syndrome in adolescence (aOR = 1.50; 95% CI = 1.06-2.12).

CONCLUSIONS:

These findings demonstrate that a poorer infant psychosocial environment was associated with greater adolescent cardiometabolic risk. The results support screening for infants' psychosocial environments and further research into causality, mechanisms, prevention, and intervention.

• Authors: Jenalee R Doom, Brie M Reid, Estela Blanco, Raquel Burrows, Betsy Lozoff, Sheila Gahagan
• Journal: The Journal of pediatrics (J Pediatr) Vol. 209 Pg. 85-91.e1 (06 2019) ISSN: 1097-6833 [Electronic] United States
• PMID: 30876752 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Anthropometry
• Birth Weight
• Body Mass Index
• Cardiovascular Diseases (epidemiology, physiopathology)
• Chile
• Cohort Studies
• Female
• Humans
• Infant
• Infant, Newborn
• Male
• Metabolic Syndrome (diagnosis, epidemiology)
• Obesity (epidemiology)
• Predictive Value of Tests
• Prevalence
• Prospective Studies
• Psychology (methods)
• Risk Assessment
• Sex Factors
• Urban Population
• Waist-Hip Ratio