The ameliorative effect of AST2017-01 in an ovalbumin-induced allergic rhinitis animal model.

Abstract

OBJECTIVE:

AST2017-01 is developed to be used for treatment and prevention of allergic diseases and composed of processed-Cordyceps militaris and processed-Rumex crispus. But, effect of AST2017-01 remains unclear in an allergic rhinitis (AR). So, this study aimed to explore the effects of AST2017-01 in ovalbumin (OVA)-induced AR animal model.

METHODS:

OVA-induced AR animals were orally administered AST2017-01 and chrysophanol, an active component of AST2017-01 for 10 days.

RESULTS:

In mice with AR, AST2017-01 and chrysophanol markedly decreased number of rubs, IgE, histamine, thymic stromal lymphopoietin, tumor necrosis factor-α, interleukin (IL)-1β, IL-4, IL-5, and IL-13 in serum or nasal mucosa tissues. Moreover, activities and protein levels of caspase-1 were markedly diminished by oral administration of AST2017-01 and chrysophanol. Declines of macrophage inflammatory protein-2, intercellular adhesion molecules-1, eosinophil, and mast cells were also noted in nasal mucosa tissues of AST2017-01 and chrysophanol groups.

CONCLUSIONS:

Taken together, these findings indicate that AST2017-01 has an anti-allergic effect as a therapeutic agent or functional food for treating and preventing AR.

• Authors: Hee-Yun Kim, Hyunwoo Jee, Jun-Ho Yeom, Hyun-Ja Jeong, Hyung-Min Kim
• Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (Inflamm Res) Vol. 68 Issue 5 Pg. 387-395 (May 2019) ISSN: 1420-908X [Electronic] Switzerland
• PMID: 30874868 (Publication Type: Journal Article)

Chemical References

• Anthraquinones
• Anti-Allergic Agents
• Cytokines
• Plant Preparations
• Ovalbumin
• Caspase 1
• chrysophanic acid

Topics

• Animals
• Anthraquinones (pharmacology, therapeutic use)
• Anti-Allergic Agents (pharmacology, therapeutic use)
• Caspase 1 (immunology)
• Cordyceps
• Cytokines (immunology)
• Disease Models, Animal
• Eosinophils (drug effects, immunology)
• Female
• Mast Cells (drug effects, immunology)
• Mice, Inbred BALB C
• Nasal Mucosa (drug effects, immunology)
• Neutrophils (drug effects, immunology)
• Ovalbumin
• Plant Preparations (pharmacology, therapeutic use)
• Rhinitis, Allergic (drug therapy, immunology)
• Rumex