Abstract | AIM: The aim of this study was to clarify whether there are more regulatory T (Treg) and regulatory B (Breg) cells, and higher levels of IL-10-related transcription factors in subcutaneous immunotherapy (SCIT)-treated pollinosis patients than in non-SCIT-treated patients. METHODS: Japanese cedar pollinosis patients undergoing SCIT had received treatment for at least 2.8 years. Peripheral blood mononuclear cells were used for flow cytometer analyses and mRNA measurement. RESULTS: The numbers of type 1 regulatory T (Tr1)-like cells and Breg cells, and expression of E4BP4 mRNA by peripheral blood mononuclear cells in SCIT-treated patients were higher than those in non-SCIT-treated patients. CONCLUSION: Tr1-like cells, Breg cells and E4BP4 may be involved in the effectiveness of SCIT.
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Authors | Masaya Matsuda, Tetsuya Terada, Nau Tsujimoto, Yuki Morie, Tomoki Ishida, Hiromu Takahashi, Junpei Hamaguchi, Yuki Tabuchi, Kana Doi, Keiki Noro, Yusuke Kikuoka, Shuji Omura, Takuya Yoshida, Yusuke Ayani, Manabu Suzuki, Takahiro Ichihara, Yuko Inaka, Takaki Inui, Ryo Kawata, Takeshi Nabe |
Journal | Immunotherapy
(Immunotherapy)
Vol. 11
Issue 6
Pg. 473-482
(04 2019)
ISSN: 1750-7448 [Electronic] England |
PMID | 30860439
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Allergens
- Antigens, Plant
- Basic-Leucine Zipper Transcription Factors
- Biomarkers
- NFIL3 protein, human
- Interleukin-10
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Allergens
(immunology)
- Antigens, Plant
(immunology)
- B-Lymphocytes, Regulatory
(immunology)
- Basic-Leucine Zipper Transcription Factors
(genetics, metabolism)
- Biomarkers
(metabolism)
- Blood Circulation
- Cryptomeria
(immunology)
- Desensitization, Immunologic
(methods)
- Female
- Humans
- Injections, Subcutaneous
- Interleukin-10
(genetics, metabolism)
- Male
- Middle Aged
- Pollen
(immunology)
- Rhinitis, Allergic, Seasonal
(immunology, therapy)
- T-Lymphocytes, Regulatory
(immunology)
- Young Adult
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