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Developmental programming: Changes in mediators of insulin sensitivity in prenatal bisphenol A-treated female sheep.

Abstract
Developmental exposure to endocrine disruptor bisphenol A (BPA) is associated with metabolic defects during adulthood. In sheep, prenatal BPA treatment causes insulin resistance (IR) and adipocyte hypertrophy in the female offspring. To determine if changes in insulin sensitivity mediators (increase in inflammation, oxidative stress, and lipotoxicity and/or decrease in adiponectin) and the intracrine steroidal milieu contributes to these metabolic perturbations, metabolic tissues collected from 21-month-old female offspring born to mothers treated with 0, 0.05, 0.5, or 5 mg/kg/day of BPA were studied. Findings showed prenatal BPA in non-monotonic manner (1) increased oxidative stress; (2) induced lipotoxicity in liver and muscle; and (3) increased aromatase and estrogen receptor expression in visceral adipose tissues. These changes are generally associated with the development of peripheral and tissue level IR and may explain the IR status and adipocyte hypertrophy observed in prenatal BPA-treated female sheep.
AuthorsMuraly Puttabyatappa, Jacob D Martin, Victoria Andriessen, Micaela Stevenson, Lixia Zeng, Subramaniam Pennathur, Vasantha Padmanabhan
JournalReproductive toxicology (Elmsford, N.Y.) (Reprod Toxicol) Vol. 85 Pg. 110-122 (04 2019) ISSN: 1873-1708 [Electronic] United States
PMID30853570 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2019 Elsevier Inc. All rights reserved.
Chemical References
  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Phenols
  • bisphenol A
Topics
  • Adipose Tissue (drug effects, metabolism)
  • Animals
  • Benzhydryl Compounds (toxicity)
  • Dyslipidemias (chemically induced)
  • Endocrine Disruptors (toxicity)
  • Female
  • Fetal Development
  • Insulin Resistance
  • Lipid Metabolism (drug effects)
  • Liver (drug effects, metabolism)
  • Maternal-Fetal Exchange
  • Muscles (drug effects, metabolism)
  • Oxidative Stress (drug effects)
  • Phenols (toxicity)
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Sheep

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