A systematic review and meta-analysis of oxaceprol in the management of osteoarthritis: An evidence from randomized parallel-group controlled trials.

Abstract

Oxaceprol, a derivative of l-proline, is an established drug for managing osteoarthritis (OA) with better safety profile than non-steroidal anti-inflammatory drugs (NSAIDs). This systematic review and meta-analysis, following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, evaluated the efficacy, safety and tolerability of oxaceprol in OA. Electronic databases for published and grey (unpublished) literature were searched to identify parallel-group randomized controlled trials (RCTs) evaluating the impact of oxaceprol in patients with OA. Risk of bias was assessed using the Cochrane collaboration's tool. A total of seven parallel-group RCTs involving 1087 participants were included in the systematic review. Meta-analysis, in Review Manager, demonstrated numerically greater/significant improvements compared to active control [diclofenac/ibuprofen]/placebo in pain and function of joint; similar improvement vs. active control in global treatment efficacy; no difference/significant difference vs. active control/placebo in NSAIDs as rescue medication. Treatment with oxaceprol showed numerically less adverse events (AEs) than active control (diclofenac: risk ratio [RR], 0.71; 95% confidence interval [CI], 0.45 to 1.11; p=0.14: ibuprofen: RR, 0.73; 95% CI, 0.30 to 1.78; p=0.49) and significantly fewer AEs compared to placebo (RR, 0.76; 95% CI, 0.63 to 0.92; p=0.004). Given the nature of small-to-moderate sample size and short duration of eligible studies, the available clinical evidence of oxaceprol in the management of OA is modest - though looks promising. New and better RCTs with larger sample size and longer follow-up are warranted to strengthen the use of oxaceprol in clinical setting for managing OA.

• Authors: Sharanbasappa Durg, Melita Lobo, Lakshmi Venkatachalam, Guruprasad Rao, Jignesh Bhate
• Journal: Pharmacological reports : PR (Pharmacol Rep) Vol. 71 Issue 2 Pg. 374-383 (Apr 2019) ISSN: 2299-5684 [Electronic] Switzerland
• PMID: 30851540 (Publication Type: Comparative Study, Journal Article, Meta-Analysis, Systematic Review)
• Copyright: Copyright © 2018 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier B.V. All rights reserved.

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antirheumatic Agents
• Diclofenac
• oxaceprol
• Hydroxyproline
• Ibuprofen

Topics

• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, adverse effects)
• Antirheumatic Agents (adverse effects, therapeutic use)
• Diclofenac (administration & dosage, adverse effects)
• Humans
• Hydroxyproline (adverse effects, therapeutic use)
• Ibuprofen (administration & dosage, adverse effects)
• Osteoarthritis (drug therapy, physiopathology)
• Randomized Controlled Trials as Topic
• Sample Size