Monodisperse and Uniform Mesoporous Silicate Nanosensitizers Achieve Low-Dose X-Ray-Induced Deep-Penetrating Photodynamic Therapy.

Abstract

X-ray-induced photodynamic therapy (X-PDT) combines both the advantages of radiotherapy (RT) and PDT, and has considerable potential applications in clinical deep-penetrating cancer therapy. However, it is still a major challenge to prepare monodisperse nanoscintillators with uniform size and high light yield. In this study, a general and rapid synthesis method is presented that can achieve large-scale preparation of monodisperse and uniform silicate nanoscintillators. By simply adjusting the metal dopants, silicate nanoscintillators with controllable size and X-ray-excited optical luminescence (450-900 nm) are synthesized by employing a general ion-incorporated silica-templating method. To make full use of external radiation, the silicate nanoscintillators are conjugated with photosensitizer rose bengal and arginylglycylaspartic acid (RGD) peptide, making them intrinsically dual-modal targeted imaging probes. Both in vitro and in vivo experiments demonstrate that the silicate nanosensitizers can accumulate effectively in tumors and achieve significant inhibitory effect on tumor progression under low-dose X-ray irradiation, while minimally affecting normal tissues. The insights gained in this study may provide an attractive route to synthesize nanosensitizers to overcome some of the limitations of RT and PDT in cancer treatment.

• Authors: Wenjing Sun, Tianhang Shi, Li Luo, Xiaomei Chen, Peng Lv, Ying Lv, Yixi Zhuang, Jinjie Zhu, Gang Liu, Xiaoyuan Chen, Hongmin Chen
• Journal: Advanced materials (Deerfield Beach, Fla.) (Adv Mater) Vol. 31 Issue 16 Pg. e1808024 (Apr 2019) ISSN: 1521-4095 [Electronic] Germany
• PMID: 30848541 (Publication Type: Journal Article)
• Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Fluorescent Dyes
• Oligopeptides
• Photosensitizing Agents
• Silicates
• Rose Bengal
• arginyl-glycyl-aspartic acid

Topics

• Animals
• Cell Line, Tumor
• Cell Survival (drug effects)
• Fluorescent Dyes (chemistry)
• Heterografts
• Humans
• Mice
• Mice, Inbred BALB C
• Nanoparticles (chemistry)
• Oligopeptides (chemistry)
• Optical Imaging
• Permeability
• Photochemotherapy (methods)
• Photosensitizing Agents (administration & dosage, chemical synthesis)
• Rose Bengal (chemistry)
• Silicates (chemistry)
• X-Rays