Abstract | BACKGROUND/AIMS: METHODS: This was a retrospective observational study reviewing the medical records of 14 patients with Temple syndrome, 7 of whom were treated with growth hormone. RESULTS: After 1 year of growth hormone treatment, the height standard deviation score (SDS) increased a median of 1.31 SDS with a median increased height velocity of 5.30 cm/year. CONCLUSIONS: These results suggest short-term improvement in height SDS with growth hormone treatment similar to the response in patients treated under the small for gestational age indication. We recommend considering growth hormone therapy in all patients with Temple syndrome who have short stature.
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Authors | Diana S Brightman, Oluwakemi Lokulo-Sodipe, Beverly A Searle, Deborah J G Mackay, Justin H Davies, I Karen Temple, Andrew Dauber |
Journal | Hormone research in paediatrics
(Horm Res Paediatr)
Vol. 90
Issue 6
Pg. 407-413
( 2018)
ISSN: 1663-2826 [Electronic] Switzerland |
PMID | 30836360
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Observational Study)
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Copyright | © 2019 S. Karger AG, Basel. |
Chemical References |
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Topics |
- Adolescent
- Adult
- Child
- Child, Preschool
- Chromosomes, Human, Pair 14
(genetics)
- DNA Methylation
- Female
- Growth Disorders
(drug therapy, genetics, pathology, physiopathology)
- Human Growth Hormone
(administration & dosage)
- Humans
- Infant
- Male
- Retrospective Studies
- Syndrome
- Uniparental Disomy
(genetics, pathology, physiopathology)
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