Synergistic activity of colistin with azidothymidine against colistin-resistant Klebsiella pneumoniae clinical isolates collected from inpatients in Greek hospitals.
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| Abstract | BACKGROUND: New antibiotics are urgently needed to treat multi-drug resistant infections; however, production of novel antibiotics is diminishing. Synergistic combination drug therapy to enhance the activity of available antibiotics may improve management of patients with resistant infections. METHODS:
Colistin-resistant Klebsiella pneumoniae isolates were collected from inpatients in 10 Greek hospitals and used to study combination activity of colistin plus azidothymidine. Combination activity was evaluated with the sum of fractional inhibitory concentrations (ΣFIC) using the mini checkerboard broth microdilution method. RESULTS: A hundred individual strains were tested. Synergistic activity was noted in 79% (79/100) of isolates and additive activity in the remaining 21% (21/100). ΣFIC50 and ΣFIC90 were 0.28 and 0.56, respectively. CONCLUSION:
Colistin with azidothymidine exhibited promising synergistic activity against colistin-resistant Klebsiella pneumoniae isolates warranting further investigation of the combination.
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| Authors | Matthew E Falagas, Georgios L Voulgaris, Kyriaki Tryfinopoulou, Panagiota Giakkoupi, Margarita Kyriakidou, Alkiviadis Vatopoulos, Anthony Coates, Yanmin Hu, Colistin - Azidothymidine Hellenic Study Group |
| Journal | International journal of antimicrobial agents (Int J Antimicrob Agents) Vol. 53 Issue 6 Pg. 855-858 (Jun 2019) ISSN: 1872-7913 [Electronic] Netherlands |
| PMID | 30836109 (Publication Type: Journal Article) |
| Copyright | Copyright © 2019 Elsevier B.V. and International Society of Chemotherapy. All rights reserved. |
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