Abstract | BACKGROUND:
Radiation therapy induces acute and chronic radiological toxicity, in particular hematological toxicity (HT). This study aimed to explore the mechanistic clue and potential predictors at the messenger RNA ( mRNA) level. MATERIALS AND METHODS: RESULTS: Eleven genes, such as ALAS2(5-aminolevulinate synthase), SLC4A1( solute carrier family 4 member 1), HBG2( hemoglobin subunit gamma 2), TNFAIP3 (TNF α-induced protein 3), PER1 (period circadian clock 1), CCDC136 (coiled-coil domain containing 136), C9orf84 (chromosome 9 open reading frame 84), IL1B ( interleukin 1β), FOSB (FosB protooncogene), NR4A2 (nuclear receptor subfamily 4), PARP15 (polymerase family member 15), had overlapping expression changes in all 3 cancers of which 3 (ALAS2, FOSB, and HBG2) are suggested as potential predictors for the early diagnosis of HT after RT. CONCLUSIONS: ALAS2, FOSB, and HBG2 may be useful predictors of HT in patients after RT. Eleven overlapping expression mRNAs among 3 cancers might be potential predictors for early diagnosis of radiation toxicity in patients.
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Authors | Yue-Hua Nie, Xiao-Dan Liu, Ruixue Huang, Da-Fei Xie, Wen-Jun Yin, Hua Guan, Zi-Jian Yu, Ping-Kun Zhou |
Journal | Dose-response : a publication of International Hormesis Society
(Dose Response)
2019 Jan-Mar
Vol. 17
Issue 1
Pg. 1559325819833474
ISSN: 1559-3258 [Print] United States |
PMID | 30833875
(Publication Type: Journal Article, Review)
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