Abstract | BACKGROUND: OBJECTIVES: METHODS: In this study, we performed metabolomic investigations into hypertension and dyslipidemia based on a "healthy" UK population. Metabolomic data from the Husermet project were acquired by gas chromatography-mass spectrometry and ultra-performance liquid chromatography-mass spectrometry. Both univariate and multivariate statistical methods were used to facilitate biomarker selection and pathway analysis. RESULTS: Serum metabolic signatures between individuals with and without hypertension or dyslipidemia exhibited considerable differences. Using rigorous selection criteria, 26 and 46 metabolites were identified as potential biomarkers of hypertension and dyslipidemia respectively. These metabolites, mainly involved in fatty acid metabolism, glycerophospholipid metabolism, alanine, aspartate and glutamate metabolism, are implicated in insulin resistance, vascular remodeling, macrophage activation and oxidised LDL formation. Remarkably, hypertension and dyslipidemia exhibit both common and distinct metabolic patterns, revealing their independent and synergetic biological implications. CONCLUSION:
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Authors | Chaofu Ke, Xiaohong Zhu, Yuxia Zhang, Yueping Shen |
Journal | Metabolomics : Official journal of the Metabolomic Society
(Metabolomics)
Vol. 14
Issue 9
Pg. 117
(08 31 2018)
ISSN: 1573-3890 [Electronic] United States |
PMID | 30830367
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Chromatography, High Pressure Liquid
- Dyslipidemias
(blood, metabolism)
- Female
- Gas Chromatography-Mass Spectrometry
- Humans
- Hypertension
(blood, metabolism)
- Male
- Metabolomics
- Middle Aged
- Young Adult
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