Chemotherapy-induced neutropenia/febrile neutropenia prophylaxis with biosimilar filgrastim in solid tumors versus hematological malignancies: MONITOR-GCSF study.

Abstract

AIM:

This study aimed to report patterns of biosimilar filgrastim prophylaxis and outcomes of chemotherapy-induced neutropenia (CIN)/febrile neutropenia (FN) in patients with hematological malignancies or solid tumors.

PATIENTS & METHODS:

MONITOR-GCSF is a real-world study of 1447 cancer patients receiving CIN/FN prophylaxis with biosimilar filgrastim (solid tumors: 77.2%; hematological malignancies: 22.8%).

RESULTS:

Differences in prophylaxis intensity and day of initiation relative to guideline recommendations were observed. In hematology patients, higher rates of CIN and FN occurred at cycle level, and rate of FN was higher at patient level (9.1 vs 5.0% in solid tumor patients).

CONCLUSION:

Adequate GCSF support in hematology and solid tumor patients is important to prevent CIN/FN and related hospitalizations and chemotherapy disturbances.

• Authors: Heinz Ludwig, Carsten Bokemeyer, Matti Aapro, Mario Boccadoro, Pere Gascón, Kris Denhaerynck, Andriy Krendyukov, Ivo Abraham, Karen MacDonald
• Journal: Future oncology (London, England) (Future Oncol) Vol. 15 Issue 8 Pg. 897-907 (Mar 2019) ISSN: 1744-8301 [Electronic] England
• PMID: 30827127 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Observational Study)

Chemical References

• Antineoplastic Agents
• Biosimilar Pharmaceuticals
• Hematologic Agents
• Filgrastim

Topics

• Aged
• Antineoplastic Agents (adverse effects)
• Biosimilar Pharmaceuticals (administration & dosage, adverse effects)
• Chemotherapy-Induced Febrile Neutropenia (etiology, prevention & control)
• Female
• Filgrastim (administration & dosage, adverse effects)
• Hematologic Agents (administration & dosage, adverse effects)
• Humans
• Male
• Middle Aged
• Neoplasms (drug therapy)
• Prospective Studies
• Treatment Outcome