Abstract | BACKGROUND: Phenolic endocrine-disrupting compounds (EDCs) have long been suspected of increasing human breast cancer risk, via aromatase up-regulation; however, the metabolic effects upon aromatase in human breast cells exposed to environmentally relevant concentrations of phenolic compounds, have not been addressed. OBJECTIVES: To examine the mechanistic responses of aromatase CYP19A1 mRNA, aromatase activity, estradiol biosynthesis and cellular proliferation, in three human breast cell lines, exposed to seven phenolic compounds, at environmentally relevant concentrations. METHODS: RESULTS: All test EDCs up-regulated aromatase mRNA, increased aromatase activity, significantly increased the aromatase-induced biosynthesis of the breast carcinogen 17β-estradiol, and increased ERα-positive breast cell proliferation. CONCLUSION:
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Authors | Graeme P Williams, Philippa D Darbre |
Journal | Molecular and cellular endocrinology
(Mol Cell Endocrinol)
Vol. 486
Pg. 55-64
(04 15 2019)
ISSN: 1872-8057 [Electronic] Ireland |
PMID | 30817981
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Elsevier B.V. All rights reserved. |
Chemical References |
- Endocrine Disruptors
- RNA, Messenger
- Receptors, Estrogen
- Fulvestrant
- Testosterone
- Estradiol
- Letrozole
- Aromatase
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Topics |
- Aromatase
(genetics, metabolism)
- Breast
(pathology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Endocrine Disruptors
(chemistry, toxicity)
- Estradiol
(biosynthesis)
- Female
- Fulvestrant
(pharmacology)
- Humans
- Letrozole
(pharmacology)
- RNA, Messenger
(genetics, metabolism)
- Receptors, Estrogen
(metabolism)
- Testosterone
(pharmacology)
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