Objective:To investigate the clinical characteristics, two different treatment outcomes and prognostic factors of hypopharyngeal
carcinoma. Method:The life table method was used to calculate the overall survival rates, Log-rank test was used to compare the overall survival rates between the two groups.The Cox proportional hazard model was used to perform the multivariate analysis to confirm independent treatment modalities as prognostic factors. Result:Among the 321 patients, 197 patients received surgery combine with
radiotherapy or
concurrent chemoradiotherapy treatment(S+R/CRT) and 124 patients received
radiotherapy or
concurrent chemoradiotherapy treatment(R/CRT). For 321 patients, the 1,3,5year overall survival rates were 75.87%,49.39%,41.38% and the median survival time was 37.65 months. The difference in throat retention ratio between the
radiotherapy or
concurrent chemoradiotherapy treatment(41.94%) and surgery combine with
radiotherapy or
concurrent chemoradiotherapy treatment(11.17%) was statistically significant (P<0.01).Univariate analysis showed that clinical stage of
tumor, T stage, N stage, M stage and two different treatment modalities have impact on survival prognosis. Cox regression multivariate analysis showed that T stage, N stage, two different treatment modalities were independent risk factors of prognosis. Conclusion:The overall prognosis of hypopharyngeal
carcinoma was poor and dismal. Hypopharyngeal
carcinoma is characterized by high degree of
malignancy, difficult to be found early, prone to recurrence and
metastasis after operation, large
trauma and poor prognosis. Comprehensive examination should be conducted to define the stage of
tumor and choose the rational treatment plan before treatment. Surgery combine with
radiotherapy or
chemotherapy treatment modality is still the main treatment strategy for advanced-stage hypopharyngeal
carcinoma..