Abstract | OBJECTIVE: METHODS: Our prospectively maintained testicular cancer database was queried to identify patients who presented with or developed clinical stage II sex cord stromal tumors and underwent RPLND at our institution between 1980 and 2018. Demographic, clinical, and pathologic characteristics were reviewed. Kaplan-Meier curves were graphed to assess recurrence-free and overall survival. RESULTS: Fourteen patients were included in the study with a median age of 44.2years. Four patients presented with clinical stage II disease and 10 patients developed metastatic disease during follow-up of initial clinical stage I disease with a median time to metastasis of 2.7years (range: 0.4-19.5 years). Of the 10 patients with orchiectomy pathology data available, all patients had at least 1 risk factor on testis pathology (mean: 2.9 risk factors). Nine patients received treatment prior to referral to our institution. All patients recurred post-RPLND at Indiana University. Median recurrence-free survival was 9.8 months. Twelve patients died of disease with a median overall survival of 14.4 months. CONCLUSION:
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Authors | Adam C Calaway, Isamu Tachibana, Timothy A Masterson, Richard S Foster, Lawrence H Einhorn, Clint Cary |
Journal | Urology
(Urology)
Vol. 127
Pg. 74-79
(05 2019)
ISSN: 1527-9995 [Electronic] United States |
PMID | 30807775
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Elsevier Inc. All rights reserved. |
Topics |
- Adult
- Cohort Studies
- Databases, Factual
- Disease-Free Survival
- Hospitals, University
- Humans
- Kaplan-Meier Estimate
- Lymph Node Excision
(methods)
- Male
- Middle Aged
- Neoplasm Invasiveness
(pathology)
- Neoplasm Recurrence, Local
(mortality, pathology)
- Neoplasm Staging
- Orchiectomy
(methods)
- Prognosis
- Retroperitoneal Space
- Retrospective Studies
- Risk Assessment
- Sex Cord-Gonadal Stromal Tumors
(mortality, pathology, surgery)
- Survival Analysis
- Testicular Neoplasms
(mortality, pathology, surgery)
- Young Adult
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