Abstract | PURPOSE: METHODS: 155 patients with muscle-invasive bladder cancer scheduled for RC completed the European Organization for Research and Treatment of Cancer questionnaires, EORTC QLQ-C30, EORTC QLQ-BLM30, Fear of Recurrence Scale, Mental Health Inventory and Satisfaction with Life Scale within 4 weeks of surgery. A propensity-matched analysis was performed comparing pre-surgery PROs among 101 patients who completed NAC versus 54 patients who did not receive NAC. We also compared PROs pre- and post- chemotherapy for 16 patients who had data available for both time points. RESULTS: In propensity-matched analysis, NAC-treated patients reported better emotional and sexual function, mental health, urinary function and fewer financial concerns compared to those that did not receive NAC. Longitudinal analysis showed increases in fatigue, nausea and appetite loss following chemotherapy. CONCLUSION: Propensity-matched analysis did not demonstrate a negative effect of NAC on PRO. Several positive associations of NAC were found in the propensity-matched analysis, possibly due to other confounding differences between the two groups or actual clinical benefit. Longitudinal analysis of a small number of patients found small to modest detrimental effects from NAC similar to toxicities previously reported. Our preliminary findings, along with known survival and toxicity data, should be considered in decision-making for NAC.
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Authors | Michael A Feuerstein, Leah Goldstein, Brieyona Reaves, Arony Sun, Michael Goltzman, Bradley A Morganstern, Ahmad Shabsigh, Dean F Bajorin, Jonathan E Rosenberg, S Machele Donat, Harry W Herr, Vincent P Laudone, Thomas M Atkinson, Yuelin Li, Guido Dalbagni, Bruce Rapkin, Bernard H Bochner |
Journal | World journal of urology
(World J Urol)
Vol. 37
Issue 11
Pg. 2401-2407
(Nov 2019)
ISSN: 1433-8726 [Electronic] Germany |
PMID | 30798382
(Publication Type: Journal Article)
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Topics |
- Aged
- Chemotherapy, Adjuvant
- Cystectomy
(methods)
- Female
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Neoadjuvant Therapy
- Patient Reported Outcome Measures
- Propensity Score
- Prospective Studies
- Urinary Bladder Neoplasms
(drug therapy, surgery)
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