Effect of stannous fluoride and zinc phosphate dentifrice on dental plaque and gingivitis: A randomized clinical trial with 6-month follow-up.

Abstract

OBJECTIVE:

The objective of this study was to compare a stabilized stannous fluoride (SnF2) dentifrice with zinc phosphate (Colgate TotalSF) with SnF2 with zinc lactate and control fluoride dentifrices for gingivitis and plaque control over a 6-month period.

METHODS:

A total of 135 adult participants were enrolled in this study. After randomization and blinding of examiners and patients, enrolled participants were provided instructions for use of assigned dentifrice. At 3 visits (0, 3, and 6 months), various gingival and plaque indexes were collected to determine the clinical efficacy of a stabilized SnF2 dentifrice. These results were compared with a SnF2 with zinc lactate dentifrice and with a control fluoride dentifrice.

RESULTS:

A total of 135 participants completed the study. All groups reported statistically significant reductions in gingival inflammation and improvement in plaque control at 3- and 6-month follow-up. Both SnF2 dentifrices showed statistically significant reductions in all indexes compared with the control dentifrice (P < .001). However, the test dentifrice showed higher but nonsignificant improvements in plaque and gingival indexes compared with the other SnF2 dentifrice.

CONCLUSIONS:

This study reports similar efficacy of a test dentifrice to a commercial SnF2-containing dentifrice for plaque control and reduction in gingival inflammation and provides supporting evidence that the test dentifrice maintains its clinical efficacy with change of formulation.

PRACTICAL IMPLICATIONS:

This newly formulated SnF2 stabilized with zinc phosphate dentifrice may be of benefit to patients in controlling plaque biofilm and gingivitis.

• Authors: Dutmanee Seriwatanachai, Terdphong Triratana, Petchart Kraivaphan, Cholticha Amaornchat, Luis R Mateo, Amarpreet Sabharwal, Evaristo Delgado, Gregory Szewczyk, Maria Ryan, Yun-Po Zhang
• Journal: Journal of the American Dental Association (1939) (J Am Dent Assoc) Vol. 150 Issue 4S Pg. S25-S31 (04 2019) ISSN: 1943-4723 [Electronic] England
• PMID: 30797256 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2019 American Dental Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• Dentifrices
• Phosphates
• Tin Fluorides
• Zinc Compounds
• zinc phosphate

Topics

• Adult
• Analysis of Variance
• Dental Plaque
• Dental Plaque Index
• Dentifrices
• Double-Blind Method
• Follow-Up Studies
• Gingivitis
• Humans
• Phosphates
• Tin Fluorides
• Zinc Compounds