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Cathepsin B: A sellsword of cancer progression.

Abstract
Clinical, biochemical and molecular biology studies have identified lysosome-encapsulated cellular proteases as critical risk factors for cancer progression. Cathepsins represent a group of such proteases aimed at maintenance of cellular homeostasis. Nevertheless, recent reports suggest that Cathepsin B executes other cellular programs such as controlling tumor growth, migration, invasion, angiogenesis, and metastases development. In fact, elevated levels of Cathepsins are found under different pathological conditions including inflammation, infection, neurodegenerative disease, and cancer. Furthermore, the discovery of Cathepsin B secretion and function as an extracellular matrix protein has broadened our appreciation for the impact of Cathepsin B on cancer progression. Underneath a façade of an intracellular protease with limited therapeutic potential hides a central role of cathepsins in extracellular functions. Moreover, this role is incredibly diverse from one condition to the next - from driving caspase-dependent apoptosis to facilitating tumor neovascularization and metastasis. Here we discuss the role of Cathepsin B in the oncogenic process and perspective the use of Cathepsin B for diagnostic and therapeutic applications.
AuthorsOlja Mijanović, Ana Branković, Alexander N Panin, Solomiia Savchuk, Peter Timashev, Ilya Ulasov, Maciej S Lesniak
JournalCancer letters (Cancer Lett) Vol. 449 Pg. 207-214 (05 01 2019) ISSN: 1872-7980 [Electronic] Ireland
PMID30796968 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2019 Elsevier B.V. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Protease Inhibitors
  • CTSB protein, human
  • Cathepsin B
Topics
  • Animals
  • Antineoplastic Agents (therapeutic use)
  • Apoptosis
  • Autophagy
  • Biomarkers, Tumor (metabolism)
  • Cathepsin B (antagonists & inhibitors, genetics, metabolism)
  • Cell Movement
  • Humans
  • Neoplasm Invasiveness
  • Neoplasms (enzymology, genetics, pathology, therapy)
  • Protease Inhibitors (therapeutic use)
  • RNAi Therapeutics
  • Signal Transduction

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