Swertiamarin decreases lipid accumulation dependent on 3-ketoacyl-coA thiolase.

Abstract

Natural compounds are important resources for drug discovery. Using Caenorhabditis elegans (C. elegans) models, we screened active natural compounds with lipid lowering effects. Swertiamarin was found as a potent candidate to reduce lipid content in C. elegans. Using RNAi screening, we were able to demonstrate that kat-1 (ketoacyl thiolase-1) is necessary for the lipid lowering effect of swertiamarin. Furthermore, the activity of swertiamarin was verified in high fat diet induced obese mice. Consistent with the results in C. elegans, swertiamarin ameliorated high fat diet induced lipid deposition and hyperlipidemia. These results indicate that swertiamarin exerts lipid-lowering effects through kat-1 regulation and could serve as a possible therapeutic option to improve hyperlipidemia induced comorbidities.

• Authors: Jianghong Wang, Jiantai He
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 112 Pg. 108668 (Apr 2019) ISSN: 1950-6007 [Electronic] France
• PMID: 30784937 (Publication Type: Journal Article)
• Copyright: Copyright © 2019. Published by Elsevier Masson SAS.

Chemical References

• Iridoid Glucosides
• Pyrones
• swertiamarin
• Acetyl-CoA C-Acyltransferase

Topics

• Acetyl-CoA C-Acyltransferase (metabolism)
• Animals
• Animals, Genetically Modified
• Caenorhabditis elegans
• Diet, High-Fat (adverse effects)
• Dose-Response Relationship, Drug
• Iridoid Glucosides (pharmacology, therapeutic use)
• Lipid Accumulation Product (drug effects, physiology)
• Male
• Mice
• Mice, Inbred C57BL
• Obesity (blood, chemically induced, drug therapy)
• Pyrones (pharmacology, therapeutic use)
• Swertia