Breast cancer risk in relation to plasma metabolites among Hispanic and African American women.

Abstract

PURPOSE:

The metabolic etiology of breast cancer has been explored in the past several years using metabolomics. However, most of these studies only included non-Hispanic White individuals.

METHODS:

To fill this gap, we performed a two-step (discovery and validation) metabolomics profiling in plasma samples from 358 breast cancer patients and 138 healthy controls. All study subjects were either Hispanics or non-Hispanic African Americans.

RESULTS:

A panel of 14 identified metabolites significantly differed between breast cancer cases and healthy controls in both the discovery and validation sets. Most of these identified metabolites were lipids. In the pathway analysis, citrate cycle (TCA cycle), arginine and proline metabolism, and linoleic acid metabolism pathways were observed, and they significantly differed between breast cancer cases and healthy controls in both sets. From those 14 metabolites, we selected 9 non-correlated metabolites to generate a metabolic risk score. Increased metabolites risk score was associated with a 1.87- and 1.63-fold increased risk of breast cancer in the discovery and validation sets, respectively (Odds ratio (OR) 1.87, 95% Confidence interval (CI) 1.50, 2.32; OR 1.63, 95% CI 1.36, 1.95).

CONCLUSIONS:

In summary, our study identified metabolic profiles and pathways that significantly differed between breast cancer cases and healthy controls in Hispanic or non-Hispanic African American women. The results from our study might provide new insights on the metabolic etiology of breast cancer.

• Authors: Hua Zhao, Jie Shen, Steven C Moore, Yuanqing Ye, Xifeng Wu, Francisco J Esteva, Debasish Tripathy, Wong-Ho Chow
• Journal: Breast cancer research and treatment (Breast Cancer Res Treat) Vol. 176 Issue 3 Pg. 687-696 (Aug 2019) ISSN: 1573-7217 [Electronic] Netherlands
• PMID: 30771047 (Publication Type: Journal Article)

Chemical References

• Biomarkers

Topics

• Adult
• Black or African American
• Biomarkers (blood)
• Breast Neoplasms (blood, epidemiology, ethnology, etiology)
• Case-Control Studies
• Comorbidity
• Disease Susceptibility
• Female
• Hispanic or Latino
• Humans
• Metabolic Networks and Pathways
• Metabolome
• Metabolomics (methods)
• Middle Aged
• Odds Ratio
• Risk Assessment
• Risk Factors