Abstract | BACKGROUND AND AIM: Due to limited data on invasive mould infections (IMIs) in the intensive care units (ICUs) of developing countries, we ascertain epidemiology and management of IMIs at 11 ICUs across India. METHODS: RESULTS: 398 patients with IMIs (96 proven, 302 probable) were identified, amounting to a prevalence of 9.5 cases/1000 ICU admissions. The mean ± SD age of the participants was 45.6 ± 21.9 years. The mean ± SD APACHE II score was 14.3 ± 11.4. The IMIs were diagnosed at a median of 4 days after ICU admission. There were 145 and 253 subjects with classical and non-classical risk groups, respectively. Although Aspergillus spp. were the commonest (82.1%) isolates, Mucorales were detected in 14.4% subjects. A high APACHE II score and IMI due to mucormycosis were significant predictors of mortality. CONCLUSIONS: The study highlights the distinct epidemiology of IMIs in India ICUs with high burden, new susceptible patient groups and considerable number of non-Aspergillus mould infections. [clinicaltrials.gov: NCT02683642].
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Authors | Arunaloke Chakrabarti, Harsimran Kaur, Jayanthi Savio, Shivaprakash M Rudramurthy, Atul Patel, Prakash Shastri, Umabala Pamidimukkala, Rajiv Karthik, Sanjay Bhattacharya, Anupma Jyoti Kindo, Pradip Bhattacharya, Subhash Todi, Ram Gopalakrishan, Pankaj Singh, Abhishek Pandey, Ritesh Agarwal |
Journal | Journal of critical care
(J Crit Care)
Vol. 51
Pg. 64-70
(06 2019)
ISSN: 1557-8615 [Electronic] United States |
PMID | 30769292
(Publication Type: Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 Elsevier Inc. All rights reserved. |
Topics |
- Adult
- Aged
- Comorbidity
- Demography
- Female
- Fungi
(isolation & purification)
- Humans
- Immunocompromised Host
- India
(epidemiology)
- Intensive Care Units
- Male
- Middle Aged
- Prevalence
- Prospective Studies
- Pulmonary Aspergillosis
(epidemiology, microbiology, mortality)
- Risk Factors
- Socioeconomic Factors
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