Abstract | Background: Epidemiologic studies on whole grains and risk of stroke have reported inconsistent results, with some suggesting a protective effect but others showing a null association. Objectives: Methods: A hospital-based case-control study was conducted between March 2011 and May 2016. Cases (n = 990) with first ischemic stroke were matched to controls (n = 990) by sex and age. Concentrations of plasma DHPPA were determined by high-performance liquid chromatography-tandem mass spectrometry. We calculated ORs for the association of plasma DHPPA concentrations with ischemic stroke risk through the use of logistic regression. Results: Plasma DHPPA was inversely associated with ischemic stroke risk. After adjustment for potential confounding factors, the ORs for ischemic stroke across increasing quartiles of plasma DHPPA concentrations were 1 (referent), 0.76 (95% CI: 0.58, 0.99), 0.71 (95% CI: 0.54, 0.92), and 0.59 (95% CI: 0.45, 0.77), respectively (P-trend = 0.001). The inverse association was also observed in all subgroups of participants according to sex, age, body mass index, smoking status, alcohol consumption, history of hypertension, and history of diabetes. Conclusions: Our study showed that higher plasma DHPPA concentrations were associated with lower risk of ischemic stroke. This finding provides further evidence to support the health benefits of whole-grain consumption.
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Authors | Taoping Sun, Yanwei Zhang, Hao Huang, Xiaoqian Wang, Li Zhou, Shuzhen Li, Suli Huang, Changhui Xie, Ying Wen, Yalun Zhu, Xiaoli Hu, Liangkai Chen, Peiyun Li, Sijing Chen, Wei Yang, Wei Bao, Frank B Hu, Jinquan Cheng, Liegang Liu |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 109
Issue 2
Pg. 1-7
(02 01 2019)
ISSN: 1938-3207 [Electronic] United States |
PMID | 30753322
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Dietary Fiber
- Phenylpropionates
- Propionates
- Resorcinols
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Topics |
- Aged
- Biomarkers
(blood)
- Brain Ischemia
(blood, prevention & control)
- Case-Control Studies
- Diet
- Dietary Fiber
(administration & dosage, therapeutic use)
- Feeding Behavior
- Female
- Humans
- Logistic Models
- Male
- Middle Aged
- Phenylpropionates
(blood)
- Propionates
(blood)
- Resorcinols
(blood)
- Secale
(chemistry)
- Stroke
(blood, prevention & control)
- Triticum
(chemistry)
- Whole Grains
(chemistry)
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