Abstract | CONTEXT: CASE: CONCLUSION: The type and severity of immune-related adverse events in polyendocrine syndrome type 2 are different and depend on the monoclonal antibody used. Although the numerous molecular mechanisms inducing autoimmune endocrine diseases are still unclear, a link exists between HLA haplotypes, gene variants involved in immune checkpoint molecule expression, and increased susceptibility to autoimmune endocrinopathies. Additional studies are needed to identify susceptible patients and adapt therapy to each patient.
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Authors | Giulia Lanzolla, Alberto Coppelli, Mirco Cosottini, Stefano Del Prato, Claudio Marcocci, Isabella Lupi |
Journal | Journal of the Endocrine Society
(J Endocr Soc)
Vol. 3
Issue 2
Pg. 496-503
(Feb 01 2019)
ISSN: 2472-1972 [Electronic] United States |
PMID | 30746508
(Publication Type: Case Reports)
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