Prognostic impact of light-chain and transthyretin-related categories in cardiac amyloidosis: A systematic review and meta-analysis.

Abstract

OBJECTIVE:

Light-chain amyloidosis and transthyretin-related amyloidosis (wild-type and mutated) are three main types of systemic amyloidosis associated with a clinically relevant cardiac involvement. In this study, we compared prognosis in patients with different categories of cardiac amyloidosis using meta-analysis and present a systematic review.

METHODS:

A systematic literature search was performed through Jan 1, 2018, and two reviewers independently extracted data and assessed risk of bias. We extracted MACE and death endpoint events and hazard ratios from regression models and performed a meta-analysis of the multiple prognosis association studies.

RESULTS:

We observed that there were significant MACE differences between patients diagnosed with transthyretin amyloidosis and light-chain amyloidosis (OR: 2.09; 95% CI: 1.06-4.12; P = 0.03), and the same is true in the sub-comparison between AL and mATTR or wtATTR (AL vs. mATTR: OR: 1.72; 95% CI: 1.06-2.82; P = 0.03; AL vs. wtATTR: OR: 1.48; 95% CI: 0.85-2.58; P = 0.17). However, no significant difference was observed between two transthyretin types (P = 0.17). Overall death rate evaluated showed that compared with transthyretin-related amyloidosis, light-chain type showed a significant difference (P < 0.05). The prognostic analysis showed that types of amyloidosis, LVEF, NYHA, restrictive filling pattern, E-wave deceleration time, E/E' ratio, and low QRS voltage were predictors of cardiac-related mortality.

CONCLUSION:

Patients diagnosed with light-chain amyloidosis has a poor prognosis compared with transthyretin-related amyloidosis, while no difference was proved in prognostic analysis between wild-type and mutated TTR amyloidosis. Some clinical factors related to the death prognosis, such as the LVEF, restrictive filling pattern, E-wave deceleration time, and E/E' ratio are important prognostic factors.

• Authors: Yanguo Xin, Wenyu Hu, Xin Chen, Jian Hu, Yingxian Sun, Yinan Zhao
• Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese (Hellenic J Cardiol) 2019 Nov - Dec Vol. 60 Issue 6 Pg. 375-383 ISSN: 2241-5955 [Electronic] Netherlands
• PMID: 30742933 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)
• Copyright: Copyright © 2019 Hellenic Society of Cardiology. Published by Elsevier B.V. All rights reserved.

Chemical References

• Prealbumin

Topics

• Adult
• Aged
• Aged, 80 and over
• Amyloid Neuropathies, Familial (metabolism, mortality, pathology)
• Cardiomyopathies (complications, mortality, physiopathology)
• Case-Control Studies
• Female
• Humans
• Immunoglobulin Light-chain Amyloidosis (metabolism, mortality, pathology)
• Male
• Middle Aged
• Prealbumin (metabolism)
• Prognosis
• Ventricular Function, Left (physiology)