Increased incidence of spondyloarthropathies in patients with Takayasu arteritis: a systematic clinical survey.

Abstract

OBJECTIVES:

Takayasu arteritis and Spondyloarthritis are two distinct inflammatory diseases that affect the same age periods. Increasing number of reports on co-incident Takayasu arteritis-spondyloarthritis cases in literature raised the hypotheses about their association. The purpose of this study is to evaluate the incidence of spondyloarthropathy spectrum diseases in Takayasu arteritis patients.

METHODS:

Detailed clinical and demographic features of Takayasu arteritis patients were recorded and all were screened meticulously for the presence of spondyloarthropathy features following recommendations of Assessment of SpondyloArthritis international Society. Patients were questioned for inflammatory back pain, enthesitis, uveitis, inflammatory bowel disease, peripheral arthritis, and investigated accordingly with HLA-B27, plain X-rays and sacroiliac magnetic resonance imaging.

RESULTS:

A total of 69 Takayasu arteritis patients (65 female, 94.2%) were enrolled. After detailed investigation, 14 (20.3%) Takayasu arteritis patients fulfilled the Assessment of SpondyloArthritis international Society criteria for Spondyloarthropathy. Two of 14 (14.2%) spondyloarthropathy patients were positive for HLA-B27. Type 1 and type 2 Takayasu arteritis were more common in patients with diagnosis of both Takayasu arteritis and spondyloarthropathy than those without spondyloarthropathy. Most of patients with diagnosis of both these diseases required biologic therapies than patients with diagnosis of Takayasu arteritis alone (64.3% vs 29.1%, P = 0.014) due to refractory Takayasu arteritis.

CONCLUSION:

Our results suggest a significant association between Takayasu arteritis and spondyloarthropathy. Possible shared genetic or immunopathogenic processes may explain this association, which merits further investigations.

• Authors: Sakine Güzel Esen, Berkan Armagan, Nuh Atas, Murat Ucar, Özkan Varan, Abdulsamet Erden, Hakan Babaoglu, Alper Sarı, Omer Karadag, Seminur Haznedaroglu, M A Öztürk, Ali Akdoğan, A Tufan
• Journal: Joint bone spine (Joint Bone Spine) Vol. 86 Issue 4 Pg. 497-501 (07 2019) ISSN: 1778-7254 [Electronic] France
• PMID: 30735804 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 Société française de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.

Topics

• Adult
• Age Distribution
• Comorbidity
• Female
• Humans
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Prevalence
• Prognosis
• Severity of Illness Index
• Sex Distribution
• Spondylarthropathies (diagnosis, epidemiology, therapy)
• Surveys and Questionnaires
• Takayasu Arteritis (diagnosis, epidemiology, therapy)
• Tomography, X-Ray Computed (methods)
• Treatment Outcome