Efficacy of High-intensity Statin Use for Transient Ischemic Attack Patients with Positive Diffusion-weighted Imaging.

Abstract

To determine whether positive or negative DWI TIA patients could get benefits from HST we conducted a cohort study which data from the prospective, hospital-based, TIA database of the First Affiliated Hospital of Zhengzhou University. The end-point was 7-day and 90-day incidence of stroke. Cox proportional hazard regression models were used to analyze the association between end-points and high-intensity statin treatment in TIA patients with positive and negative DWI. A total of 987 eligible TIA patients were analyzed. The stroke risk of patients with positive DWI was about a four-fold increase compared to that with negative DWI (7 d, 10.9 versus 1.8, p < 0.001 and 90 d, 18.3 versus 4.2, p < 0.001). After adjusting confounding factors, HST significantly improved both 7-day (HR 0.331, 95% CI 0.165-0.663; p = 0.002) and 90-day (HR 0.480, 95% CI 0.288-0.799; p = 0.005) outcomes in positive DWI patients. As a conclusion, high-intensity statin use reduces the 90 days' recurrent stroke risk in DWI-positive TIA patients but not in DWI-negative patients.

• Authors: Bo Song, Yuan Cao, Lulu Pei, Hui Fang, Lu Zhao, Pei Chen, Pan Si, Xinjing Liu, Kai Liu, Yuan Gao, Jun Wu, Shilei Sun, Xiaoying Wang, Eng H Lo, Ferdinando S Buonanno, Mingming Ning, Yuming Xu
• Journal: Scientific reports (Sci Rep) Vol. 9 Issue 1 Pg. 1173 (02 04 2019) ISSN: 2045-2322 [Electronic] England
• PMID: 30718523 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hydroxymethylglutaryl-CoA Reductase Inhibitors

Topics

• Adult
• Aged
• China
• Female
• Hospitals
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (administration & dosage)
• Ischemic Attack, Transient (drug therapy)
• Male
• Middle Aged
• Prospective Studies
• Stroke (prevention & control)
• Treatment Outcome