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A FRET-based ratiometric fluorescent probe for detection of intrinsically generated SO2 derivatives in mitochondria.

Abstract
A mitochondria-targeted ratiometric fluorescent probe based on hemicyanine and pyrido[1,2-a]benzimidazole was presented. It shows high sensitivity and selectivity toward SO2 in pure water. The limit of detection (LOD) was as low as 26.7 nM, which is superior to most reported probes. Most importantly, the probe was successfully used for fluorescence imaging of endogenous bisulfite in mitochondria in Glioma cells.
AuthorsGuangle Song, Aikun Liu, Hongli Jiang, Ruixue Ji, Jian Dong, Yanqing Ge
JournalAnalytica chimica acta (Anal Chim Acta) Vol. 1053 Pg. 148-154 (Apr 11 2019) ISSN: 1873-4324 [Electronic] Netherlands
PMID30712560 (Publication Type: Journal Article)
CopyrightCopyright © 2018 Elsevier B.V. All rights reserved.
Chemical References
  • Fluorescent Dyes
  • Sulfur Dioxide
Topics
  • Cell Line, Tumor
  • Fluorescence Resonance Energy Transfer (methods)
  • Fluorescent Dyes (metabolism)
  • Humans
  • Kinetics
  • Limit of Detection
  • Mitochondria (metabolism)
  • Optical Imaging
  • Sulfur Dioxide (chemistry, metabolism)

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