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A selective chemiresistive sensor for the cancer-related volatile organic compound hexanal by using molecularly imprinted polymers and multiwalled carbon nanotubes.

Abstract
A chemiresistive sensor is described for the lung cancer biomarker hexanal. A composite consisting of molecularly imprinted polymer nanoparticles and multiwalled carbon nanotubes was used in the sensor that is typically operated at a voltage of 4 V and is capable of selectively sensing gaseous hexanal at room temperature. It works in the 10 to 200 ppm concentration range and has a 10 ppm detection limit (at S/N = 3). The sensor signal recovers to a value close to its starting value without the need for heating even after exposure to relatively high levels of hexanal. Graphical abstract Schematic presentation of a chemiresistive sensor for detection of hexanal, a cancer biomarker. The hexanal-imprinted polymeric nanoparticles were synthesized, mixed with multiwalled carbon nanotubes and coated on the surface of an interdigitated electrode to produce a nanocomposite chemiresistor gas sensor for hexanal.
AuthorsSajjad Janfaza, Maryam Banan Nojavani, Maryam Nikkhah, Taher Alizadeh, Ali Esfandiar, Mohammad Reza Ganjali
JournalMikrochimica acta (Mikrochim Acta) Vol. 186 Issue 3 Pg. 137 (02 01 2019) ISSN: 1436-5073 [Electronic] Austria
PMID30707323 (Publication Type: Journal Article)
Chemical References
  • Aldehydes
  • Biomarkers, Tumor
  • Gases
  • Methacrylates
  • Nanotubes, Carbon
  • Volatile Organic Compounds
  • methacrylic acid
  • Polymethyl Methacrylate
  • n-hexanal
Topics
  • Aldehydes (analysis)
  • Biomarkers, Tumor (analysis)
  • Biosensing Techniques
  • Electrochemical Techniques
  • Electrodes
  • Gases (chemistry)
  • Humans
  • Limit of Detection
  • Lung Neoplasms (diagnosis)
  • Methacrylates (chemistry)
  • Molecular Imprinting
  • Nanocomposites (chemistry)
  • Nanoparticles (chemistry)
  • Nanotubes, Carbon (chemistry)
  • Particle Size
  • Polymerization
  • Polymethyl Methacrylate (chemistry)
  • Surface Properties
  • Temperature
  • Volatile Organic Compounds (analysis)

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