Abstract | BACKGROUND: METHODS: We conducted a cross-sectional study to examine the relationship between n-3 PUFAs and FCR among breast cancer survivors. Adults who had been diagnosed with invasive breast cancer and were not undergoing chemotherapy were asked to participate. Blood PUFA composition was evaluated by using capillary blood. We directly administered the Concerns About Recurrence Scale (CARS) to assess the grade of FCR. RESULTS: Among 126 participants used for the analysis, the mean age (SD) was 58 (11) years and 47% had stage I cancer. Multiple regression analysis controlling for possible confounders, depressive symptoms, and post-traumatic stress disorder ( PTSD) symptoms revealed that the alpha-linolenic acid (ALA) level was significantly inversely associated with the average score on the CARS overall fear index (beta = -0.165, p = 0.04). No significant associations were found for other PUFAs. LIMITATIONS: Our findings were obtained from a cross-sectional study in a single institute. CONCLUSION: These findings provide the first evidence of a beneficial effect of ALA on FCR and indicate the need for prospective study of this association. FCR among breast cancer survivors might be controllable by prudent selection of ALA-containing cooking oil.
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Authors | Ryo Okubo, Hiroko Noguchi, Kei Hamazaki, Masayuki Sekiguchi, Takayuki Kinoshita, Noriko Katsumata, Tomomi Narisawa, Yasuhito Uezono, Jinzhong Xiao, Yutaka J Matsuoka |
Journal | Journal of affective disorders
(J Affect Disord)
Vol. 245
Pg. 1114-1118
(02 15 2019)
ISSN: 1573-2517 [Electronic] Netherlands |
PMID | 30699854
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 Elsevier B.V. All rights reserved. |
Chemical References |
- Fatty Acids, Omega-3
- alpha-Linolenic Acid
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Topics |
- Aged
- Breast Neoplasms
(psychology)
- Cancer Survivors
(psychology)
- Cross-Sectional Studies
- Depression
(blood, psychology)
- Fatty Acids, Omega-3
- Fear
(psychology)
- Female
- Humans
- Memory
- Middle Aged
- Multivariate Analysis
- Neoplasm Recurrence, Local
(psychology)
- Phobic Disorders
(blood, psychology)
- Stress Disorders, Post-Traumatic
(blood, psychology)
- alpha-Linolenic Acid
(blood)
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