The Adverse Events Rate of Endothelial Progenitor Cell Capturing Stent in the Treatment of CAD Patients.

Abstract

BACKGROUND:

Circulating endothelial progenitor cells (EPCs) have regenerative capacities and play an important role in vessel wall homeostasis. When attracted to the site of vessel wall injury, EPCs rapidly differentiate into a functional layer as part of the healing process. The Genous TM endothelial progenitor cell (EPC) capturing stent is coated with anti-human CD34+ antibodies which combine with circulating EPCs from the peripheral blood to the stent surface.

OBJECTIVE:

This meta-analysis aims to explore the Genous TM endothelial progenitor cell capturing stent in coronary artery disease (CAD) adverse event rate after one-year follow-up.

METHODS:

PubMed, EMBASE and, Google Scholar databases were searched for eligible studies. CAD survival data and clinicopathological features were analyzed by expected shortfall (ES) and 95% CI. Fixed-effect model and random-effect model are used for summary statistics.

RESULTS:

12 studies, including 15985 coronary artery disease (CAD) patients who received PCI treatment were included in this study. After 1-year follow-up, the rate of adverse event showed that the target vessel failure (TVF) was 8.5% (7.6%-17.4%), target vessel revascularization was 4.1% (TVR, 0-15.6%), target lesion revascularization was 4.2% (TLR, 3.7%-22%), myocardial infarction was 2.0% (MI, 1.8%-5.2%), major adverse cardiac events was 8.7% (MACE, 6.4%-28%), and the all-cause death was 4.0% (0-9.2).

CONCLUSION:

After one-year follow-up, the incidence rate of Genous stent adverse events was stable in CAD patients. The study showed a better evaluation of Genous stent, and it provides a better reference for CAD clinical treatment.

• Authors: Wei-Yuan Xu, Wei-Liang Tang, Min Yuan, Yong Sun, Feng Xu, Fang Peng
• Journal: Combinatorial chemistry & high throughput screening (Comb Chem High Throughput Screen) Vol. 21 Issue 10 Pg. 725-733 ( 2018) ISSN: 1875-5402 [Electronic] United Arab Emirates
• PMID: 30698109 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Topics

• Coronary Artery Disease (drug therapy, pathology)
• Endothelial Progenitor Cells (drug effects, pathology)
• Humans
• Stents (adverse effects)