Acyl-CoA: cholesterol acyltransferases-2 gene polymorphism is associated with increased susceptibility to coronary artery disease in Uygur population in Xinjiang, China.

Abstract

BACKGROUND:

Acyl-CoA: cholesterol acyltransferases (ACAT) is the only enzyme that catalyzes the synthesis of cholesterol esters (CE) from free cholesterol and long-chain fatty acyl-CoA and plays a critical role in cellular cholesterol homeostasis. In the present study, our primary objective was to explore whether the single-nucleotide polymorphisms (SNPs) in ACAT-2 gene were associated with coronary artery disease (CAD) in Uygur subjects, in Xinjiang, China.

METHODS:

We designed a case-control study including 516 CAD patients and 318 age- and sex-matched control subjects. Using the improved multiplex ligation detection reaction (iMLDR) method, we genotyped two SNPs (rs28765985 and rs7308390) of ACAT-2 gene in all subjects.

RESULTS:

We found that the genotypes, the dominant model (CC + CT vs TT) and over-dominant model (CT vs CC + TT) of rs28765985 were significantly different between CAD patients and the controls (P=0.027, P=0.012 and P=0.035, respectively). The rs28765985 C allele was associated with a significantly elevated CAD risk [CC/CT vs TT: odds ratio (OR) = 1.48, 95% confidence interval (CI) = 1.02-2.16, P=0.04] after adjustment for confounders. The TC and LDL-C levels were significantly higher in rs28765985 CC/CT genotypes than that in TT genotypes (P<0.05).

CONCLUSIONS:

Rs28765985 of ACAT-2 gene are associated with CAD in Uygur subjects. Subjects with CC/CT genotype or C allele of rs28765985 were associated with an increased risk of CAD.

• Authors: Yong-Tao Wang, Buamina Maitusong, Yi-Tong Ma, Zhen-Yan Fu, Yi-Ning Yang, Xiang Ma, Xiao-Mei Li, Fen Liu, Bang-Dang Chen
• Journal: Bioscience reports (Biosci Rep) Vol. 39 Issue 2 (02 28 2019) ISSN: 1573-4935 [Electronic] England
• PMID: 30696703 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 The Author(s).

Chemical References

• Cholesterol, LDL
• Sterol O-Acyltransferase

Topics

• Aged
• Case-Control Studies
• China (ethnology)
• Cholesterol, LDL (blood)
• Coronary Artery Disease (blood, genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Sterol O-Acyltransferase (genetics)
• Sterol O-Acyltransferase 2