Abstract | BACKGROUND:
Dupuytren's disease causes a flexion contracture of the hand that limits hand function and reduces quality of life. Traditional management is surgical excision which is associated with potentially serious complications. A viable alternative is collagenase Clostridium histolyticum (CCH) (Xiaflex®; Pfizer Australia) which is an effective, safe, outpatient treatment that to date has no published data in the Australian public health setting. METHODS: A prospective cohort, single centre study, enrolling 54 patients to treat 81 joints with CCH. Patients received a single dose to the cord followed by joint manipulation 48 h later. Primary endpoint was reduction in contracture to 0 to 5° of full extension assessed 4 weeks after injection. Secondary endpoints included range of motion, patient satisfaction and function as measured by the Southampton Dupuytren's Scoring Scheme (SDSS). RESULTS: Primary endpoint was achieved in 48% of joints (66% metacarpophalangeal and 19% proximal interphalangeal). Mean flexion contracture improved by 40o and 25o for metacarpophalangeal and proximal interphalangeal joints, respectively. Mean active range of motion improved by 39o and 18o , respectively. At 30 days and 12 months, SDSS score demonstrated sustained improvement versus baseline (1.88 versus 8.24 P ≤ 0.0005 and 1.59 versus 8.07 P ≤ 0.0005). Sixty-eight percent of patients were either very satisfied or satisfied at 12-month follow-up. Side effects of treatment were minor; with oedema and bruising the most common (87% and 85%, respectively). CONCLUSION:
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Authors | Jason Fletcher, Ezekiel S L Tan, Michael Thomas, Fraser Taylor, Devlin Elliott, Randy Bindra |
Journal | ANZ journal of surgery
(ANZ J Surg)
Vol. 89
Issue 5
Pg. 573-577
(05 2019)
ISSN: 1445-2197 [Electronic] Australia |
PMID | 30685881
(Publication Type: Journal Article)
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Copyright | © 2019 Royal Australasian College of Surgeons. |
Chemical References |
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Topics |
- Aged
- Collagenases
(administration & dosage)
- Dupuytren Contracture
(drug therapy, physiopathology)
- Female
- Finger Joint
(physiopathology)
- Follow-Up Studies
- Humans
- Injections, Intralesional
- Male
- Patient Satisfaction
- Prospective Studies
- Public Health
- Range of Motion, Articular
(physiology)
- Treatment Outcome
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