Biochemical pharmacology of Gilles de la Tourette's syndrome.

Abstract

A comprehensive brief review of Tourette's syndrome has been presented. This included description of various symptoms display, neuropathological findings, biochemical and pharmacological studies. An outline of pharmacotherapy and pharmacological properties of agents used in management of Tourette's syndrome has been made. They were classified according to their effect in modulating biogenic amine systems. Drugs producing exacerbation of Tourette's syndrome were also surveyed. Biochemical and pharmacological hypotheses relevant to the underlying pathology of the disease have been addressed and discussed.

• Authors: F S Messiha
• Journal: Neuroscience and biobehavioral reviews (Neurosci Biobehav Rev) 1988 Fall-Winter Vol. 12 Issue 3-4 Pg. 295-305 ISSN: 0149-7634 [Print] United States
• PMID: 3067157 (Publication Type: Journal Article, Review)

Chemical References

• Biogenic Amines
• Pimozide
• Lithium
• Haloperidol

Topics

• Biogenic Amines (metabolism)
• Haloperidol (therapeutic use)
• Humans
• Lithium (therapeutic use)
• Pimozide (therapeutic use)
• Tourette Syndrome (drug therapy, metabolism)