Abstract | BACKGROUND/AIMS: MATERIALS AND METHODS: Overall, 25 patients with hemodialysis-dependent CRF who were infected with genotype 1a/1b HCV have been treated using the 3D regimen in our gastroenterology clinic between July 2016 and October 2017. Three patients were administered additional ribavirin 200 mg/day. Serum HCV RNAs, blood chemistry, blood count, and side effects were recorded at 0, 4, and 12 weeks. RESULTS: All 25 patients completed and well tolerated their planned treatment. At the end of 4 weeks, the viral response (defined as HCV RNA clearance) rate was 92%. At the end of 12 weeks of treatment and 3 months after treatment, viral response rates were both 100%. CONCLUSION: We observed that the treatment with 3D regimen in hemodialysis patients infected with genotype 1 hepatitis C is highly effective and well tolerated.
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Authors | Serkan Yaraş, Enver Üçbilek, Osman Özdoğan, Fehmi Ateş, Engin Altıntaş, Orhan Sezgin |
Journal | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
(Turk J Gastroenterol)
Vol. 30
Issue 4
Pg. 331-335
(Apr 2019)
ISSN: 2148-5607 [Electronic] Turkey |
PMID | 30666967
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Anilides
- Antiviral Agents
- Carbamates
- Cyclopropanes
- Lactams, Macrocyclic
- Macrocyclic Compounds
- Sulfonamides
- ombitasvir
- Uracil
- Proline
- 2-Naphthylamine
- dasabuvir
- Valine
- Ritonavir
- paritaprevir
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Topics |
- 2-Naphthylamine
- Adult
- Aged
- Anilides
(administration & dosage)
- Antiviral Agents
(administration & dosage)
- Carbamates
(administration & dosage)
- Cyclopropanes
- Drug Therapy, Combination
- Female
- Genotype
- Hepacivirus
(drug effects, genetics)
- Hepatitis C, Chronic
(complications, drug therapy)
- Humans
- Kidney Failure, Chronic
(therapy, virology)
- Lactams, Macrocyclic
- Macrocyclic Compounds
(administration & dosage)
- Male
- Middle Aged
- Proline
(analogs & derivatives)
- Renal Dialysis
- Ritonavir
(administration & dosage)
- Sulfonamides
(administration & dosage)
- Sustained Virologic Response
- Turkey
- Uracil
(administration & dosage, analogs & derivatives)
- Valine
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