Quinolone hybrids and their anti-cancer activities: An overview.

Abstract

The global pandemic of drug-sensitive cancers and the increasing threat from drug-resistant cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone derivatives possess promising anti-cancer activity, and some of them have already been approved to treat cancers or under clinical trials. Hybridization of quinolone with other anti-cancer pharmacophores may provide more efficient anti-cancer candidates, so quinolone hybrids worth to be investigated. In this review, the recent advances in the development of novel quinolone hybrids as potential anti-cancer agents are highlighted, and the structure-activity relationship is also discussed to provide an insight for further development of more active quinolone hybrids.

• Authors: Feng Gao, Xia Zhang, Tengfei Wang, Jiaqi Xiao
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 165 Pg. 59-79 (Mar 01 2019) ISSN: 1768-3254 [Electronic] France
• PMID: 30660827 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2019 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antineoplastic Agents
• Quinolones

Topics

• Animals
• Antineoplastic Agents (chemistry, pharmacology)
• Humans
• Neoplasms (drug therapy)
• Quinolones (chemistry, pharmacology, therapeutic use)
• Structure-Activity Relationship