Abstract | BACKGROUND: METHODS: Serum samples and general clinical information were obtained from 672 subjects including 364 PCAD subjects, 126 non-PCAD subjects, and 182 controls. RESULTS: Serum clusterin levels were higher in PCAD patients than in controls, particularly in males with body mass index (BMI) < 25 kg/m2 (P < 0.0001). Compared with the lowest tertile of clusterin, the odds ratio of PCAD in the highest tertile was higher in both a univariate and three adjustment models, and it was 3.146-fold higher in Model 3. This association was especially significant in subgroups with BMI < 25 kg/m2 , total cholesterol < 5.7 mmol/L, high-density lipoprotein cholesterol ≥ 1.0 mmol/L, Urea < 7.14 mmol/L, and estimated glomerular filtration rate < 90 mL/min/1.73 m2 . Serum clusterin may be a potential diagnostic biomarker for PCAD (sensitivity 60.7%, specificity 51.6%, area under the curve 0.595 [95% CI, 0.544-0.647], P < 0.0001), and a combination of clusterin with clinical variables in Model 3 resulted in improved diagnostic accuracy (sensitivity 86.3%, specificity 64.2%, area under the curve 0.829 [95% CI, 0.782-0.877], P < 0.0001). CONCLUSIONS: Serum clusterin levels were increased in PCAD patients, especially for males with BMI < 25 kg/m2 . Higher clusterin levels were independently associated with the presence of PCAD, particularly in subjects with normal BMI, lower total cholesterol, urea, estimated glomerular filtration rate, and higher high-density lipoprotein cholesterol. Clusterin might be a potential diagnostic biomarker for PCAD patients, especially in combination with clinical variables.
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Authors | Huijuan Zhu, Meijuan Liu, Tianshu Zhai, Hui Pan, Linjie Wang, Hongbo Yang, Kemin Yan, Fengying Gong, Yong Zeng |
Journal | Diabetes/metabolism research and reviews
(Diabetes Metab Res Rev)
Vol. 35
Issue 4
Pg. e3128
(05 2019)
ISSN: 1520-7560 [Electronic] England |
PMID | 30659732
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2019 John Wiley & Sons, Ltd. |
Chemical References |
- Biomarkers
- CLU protein, human
- Clusterin
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Topics |
- Biomarkers
(blood)
- Case-Control Studies
- China
(epidemiology)
- Clusterin
(blood)
- Coronary Artery Disease
(blood, classification, diagnosis, epidemiology)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Prognosis
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