Topical oral 1-tetradecanol complex in the treatment of periodontal diseases in cats.

Abstract

OBJECTIVES:

The aim of this study was to evaluate the outcomes of the treatment of chronic periodontal disease with an oral application of tetradecanol complex (1-TDC) in cats.

METHODS:

The test group (n = 9) received 1-TDC (525 mg per gel capsule/day) and the placebo group (n = 4) received olive oil (0.25 ml per gel capsule/day) for 6 weeks.

RESULTS:

Oral treatment with 1-TDC resulted in significant reductions in all parameters of clinical periodontal disease except tooth mobility at 6 weeks. The 1-TDC group exhibited a statistically significant reduction in pocket depth, clinical attachment loss, gingival index and bleeding on probing after treatment at 6 weeks, whereas the placebo group did not show any significant change.

CONCLUSIONS AND RELEVANCE:

Chronic inflammation associated with periodontal diseases leads to periodontal tissue destruction. As a result, modulation of the host response has been included in the treatment protocol for periodontal diseases. Fatty acids present anti-inflammatory properties and are being investigated for use in the treatment and prevention of progressive periodontal diseases.

• Authors: Fernanda Maria Lopes Kubitza, James Mudie George Anthony
• Journal: Journal of feline medicine and surgery (J Feline Med Surg) Vol. 21 Issue 12 Pg. 1141-1148 (12 2019) ISSN: 1532-2750 [Electronic] England
• PMID: 30652935 (Publication Type: Journal Article, Randomized Controlled Trial, Veterinary)

Chemical References

• Anti-Inflammatory Agents
• Fatty Alcohols
• myristyl alcohol

Topics

• Administration, Topical
• Animals
• Anti-Inflammatory Agents (administration & dosage)
• Cat Diseases (drug therapy)
• Cats
• Fatty Alcohols (administration & dosage)
• Periodontal Diseases (drug therapy, veterinary)