Roles of highly expressed PAICS in lung adenocarcinoma.

Abstract

BACKGROUND:

Phosphoribosylaminoimidazole carboxylase (PAICS), a de novo purine metabolic enzyme, has been identified as an oncogene in several tumor types, including breast cancer and prostate cancer. However, the role of PAICS in human lung adenocarcinoma (LADC) requires further study.

METHODS:

In this research, the effects of PAICS on the occurrence and prognosis of LADC were evaluated using integrative bioinformatics analyses.

RESULTS:

By employing the bioinformatics analyses of several public databases, PAICS, which is overexpressed in the LADC tissues, was identified as a potential tumor-promoting gene in LADC biology. Several relevant clinical studies indicated that the upregulation of PAICS was statistically correlated with a shorter overall survival time. Moreover, the carcinogenic function of PAICS in LADC was validated by the further protein-protein interactions (PPI) and biological process annotation analysis. Mechanistically, we found that the PAICS methylation level was significantly lower in the LADC tissues compared to the normal lung tissues. Furthermore, using the MEXPRESS web tool, we predicted 15 possible DNA methylation sites in the nucleotide sequences of PAICS, which could explain the alteration in the PAICS expression levels in LADC.

CONCLUSIONS:

Our work demonstrates that high levels of PAICS are found in LADC and that this gene may be a potential therapeutic target for this subset of lung cancers. Determining the detailed roles of PAICS in LADC biology may provide useful information for further investigations.

• Authors: Shuyi Zhou, Yuanliang Yan, Xi Chen, Xiang Wang, Shuangshuang Zeng, Long Qian, Jie Wei, Xue Yang, Yangying Zhou, Zhicheng Gong, Zhijie Xu
• Journal: Gene (Gene) Vol. 692 Pg. 1-8 (Apr 15 2019) ISSN: 1879-0038 [Electronic] Netherlands
• PMID: 30641222 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers, Tumor
• EGFR protein, human
• ErbB Receptors
• Carboxy-Lyases
• phosphoribosylaminoimidazole carboxylase

Topics

• Adenocarcinoma of Lung (genetics, metabolism, mortality)
• Biomarkers, Tumor (genetics, metabolism)
• Carboxy-Lyases (genetics, metabolism)
• DNA Methylation
• ErbB Receptors (genetics)
• Female
• Gene Expression Regulation, Enzymologic
• Gene Expression Regulation, Neoplastic
• Humans
• Lung Neoplasms (genetics, metabolism, mortality)
• Male
• Prognosis
• Protein Interaction Maps