Abstract | BACKGROUND AND PURPOSE: METHODS: We retrospectively analyzed the records of 70 children and adolescents with FCD types I, II, and IIIa who underwent resective epilepsy surgery between 2004 and 2015 and were followed for at least 2 years after surgery. RESULTS: We attempted AED withdrawal in 40 patients. The median time of starting the AED reduction was 10.8 months after surgery. Of these 40 patients, 14 patients (35%) experienced seizure recurrence during AED reduction or after AED withdrawal. Half of the 14 patients who experienced recurrence regained seizure freedom after AED reintroduction and optimization. Compared with their preoperative status, the AED dose or number was decreased in 57.1% of patients, and remained unchanged in 14.3% after surgery. A multivariate analysis found that incomplete resection (p=0.004) and epileptic discharges on the postoperative EEG (p=0.025) were important predictors of seizure recurrence after AED withdrawal. Over the mean follow-up duration of 4.5 years after surgery, 34 patients (48.6% of the entire cohort) were seizure-free with and without AEDs. CONCLUSIONS: Children with incomplete resection and epileptic discharges on postoperative EEG are at a high risk of seizure recurrence after drug withdrawal. Complete resection of FCD may lead to a favorable surgical outcome and successful AED withdrawal after surgery.
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Authors | Sun Ah Choi, Soo Yeon Kim, Woo Joong Kim, Young Kyu Shim, Hunmin Kim, Hee Hwang, Ji Eun Choi, Byung Chan Lim, Jong Hee Chae, Sangjoon Chong, Ji Yeoun Lee, Ji Hoon Phi, Seung Ki Kim, Kyu Chang Wang, Ki Joong Kim |
Journal | Journal of clinical neurology (Seoul, Korea)
(J Clin Neurol)
Vol. 15
Issue 1
Pg. 84-89
(Jan 2019)
ISSN: 1738-6586 [Print] Korea (South) |
PMID | 30618221
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Korean Neurological Association. |