Oral faecal microbiota transplantation for the treatment of Clostridium difficile-associated diarrhoea in a dog: a case report.

Abstract

BACKGROUND:

Successful clinical outcomes of faecal microbiota transplantation (FMT) for recurrent Clostridium difficile infection have been reported in humans and a marmoset. However, it has been unclear whether oral FMT was effective for the treatment of C. difficile-associated diarrhoea in dogs.

CASE PRESENTATION:

An 8-month-old, intact male French bulldog was presented with a 4-month history of intermittent large bowel diarrhoea. Physical and clinical examinations did not identify any specific causes for diarrhoea. Real-time PCR analysis and immunochromatography detected C. difficile antigen and toxin A&B genes and proteins in a faecal sample. Based on these findings, diarrhoea in the dog was considered to be induced by C. difficile-associated colitis. The dog was treated with oral FMT, in which a faecal solution obtained from a healthy beagle was orally administered to the subject. Stool consistency and frequency and faecal blood and mucus became normal 2-3 days after oral FMT, and real-time PCR analysis and immunochromatography was negative for C. difficile antigen and toxin A&B genes and proteins. No adverse events were observed.

CONCLUSION:

The present case report demonstrated that oral FMT was an effective treatment for C. difficile-associated diarrhoea in a dog. The findings in this report provide a rationale to evaluate clinical efficacy of oral FMT for other gastrointestinal diseases in dogs.

• Authors: Koji Sugita, Nanako Yanuma, Hikaru Ohno, Kaho Takahashi, Koji Kawano, Hidetoshi Morita, Keitaro Ohmori
• Journal: BMC veterinary research (BMC Vet Res) Vol. 15 Issue 1 Pg. 11 (Jan 07 2019) ISSN: 1746-6148 [Electronic] England
• PMID: 30616615 (Publication Type: Case Reports, Journal Article)

Topics

• Animals
• Clostridioides difficile
• Clostridium Infections (diagnosis, microbiology, therapy, veterinary)
• Diarrhea (microbiology, therapy, veterinary)
• Dog Diseases (diagnosis, microbiology, therapy)
• Dogs
• Fecal Microbiota Transplantation (veterinary)
• Male
• Real-Time Polymerase Chain Reaction (veterinary)