No Relationships between Psychosis and the Diazepam Binding Inhibitor rs2276596 (C/A) Polymorphism in Japanese: An Exploratory Study.

Abstract

OBJECTIVE:

Our recent study for the first time reported genotyping method of the diazepam binding inhibitor (DBI) rs2276596 polymorphism using a Polymerase Chain Reaction-Restriction Fragment Length Polymor- phism (PCR-RFLP), and revealed a significant relationships between this polymorphism and alcohol depend- ence. In this study, to facilitate elucidation of the pathogeneses of psychoses including schizophrenia and mood (affective) disorders, we investigated the relationship between the DBI rs2276596 polymorphism (C/A) and psychoses.

METHOD:

We analyzed the DBI genotypes using the PCR-RFLP method in healthy controls, and psychotics including schizophrenia and mood (affective) disorders (including recurrent depressive disorder and bipolar affective disorder) (ICD-10: F31, F33).

RESULT:

There was no significant difference in the rs2276596 genotype and allele frequencies of the DBI gene between these psychoses and healthy controls.

CONCLUSION:

The present data suggested that a mutated allele of the DBI was not one of the risk factors for schizophrenia and mood (affective) disorders, as for the rs2276596 polymorphism. [Original].

• Authors: Eiji Yoshiharia, Shin Narita, Chikako Waga, Maki Numajiri, Yuya Onozawa, Kazuhiko Iwahashi
• Journal: Rinsho byori. The Japanese journal of clinical pathology (Rinsho Byori) Vol. 64 Issue 9 Pg. 1007-1011 (09 2016) ISSN: 0047-1860 [Print] Japan
• PMID: 30609452 (Publication Type: Journal Article)

Chemical References

• Diazepam Binding Inhibitor

Topics

• Adult
• Alleles
• Asian People (genetics)
• Diazepam Binding Inhibitor (genetics)
• Female
• Genotype
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Psychotic Disorders (genetics)