Multiple remissions of extracavitary primary effusion lymphoma treated with a single cycle of liposomal doxorubicin in a patient infected with HIV.

Abstract

Primary effusion lymphoma (pel) is a rare human herpesvirus 8 (hhv8)-related large B cell lymphoma with plasmablastic, immunoblastic, or anaplastic features that often carries a poor prognosis. This lymphoma occurs mainly in patients with hiv infection, most often with Epstein-Barr virus (ebv) co-infection, and usually presents as body cavity effusions or, less commonly, as extracavitary lesions without effusion (ec-pel). Chemotherapeutic treatment options are limited and require concurrent antiretroviral therapy (art). Here, we report the case of an adult patient with hiv infection and chronic hepatitis E virus (hev) co-infection who had low CD4 T cell recovery after years of art. The patient then developed a cutaneous ec-pel which rapidly regressed after 1 cycle of liposomal doxorubicin (ld) for his Kaposi sarcoma (ks) before treatment with chop chemotherapy. He had previously received numerous cycles of ld for cutaneous ks over 2 years. Because of the patient's low CD4 T cell count, hev co-infection, and earlier unexpected remission of ec-pel before chop, the patient opted for a single trial of ld before other options. Surprisingly, he experienced a complete remission lasting 18 months. Subsequently, his ec-pel relapsed twice at 31 and at 41 months after the initial diagnosis. Upon recurrence, a similar single cycle of ld was given, which again induced remission. The patient today is in complete remission after a total of 4 ld infusions over 54 months. This patient represents a unique case of hiv-with-hhv8-related, ebv-negative ec-pel with chronic hev coinfection, in which rapid remission was achieved after a single cycle of ld, suggesting an antiviral response in addition to the chemotherapeutic effect.

• Authors: J Chen, V Mehraj, J Szabo, B Routy, R P Michel, J P Routy
• Journal: Current oncology (Toronto, Ont.) (Curr Oncol) Vol. 25 Issue 6 Pg. e592-e596 (12 2018) ISSN: 1718-7729 [Electronic] Switzerland
• PMID: 30607128 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• liposomal doxorubicin
• Polyethylene Glycols
• Doxorubicin

Topics

• Antibiotics, Antineoplastic (administration & dosage, adverse effects, therapeutic use)
• Biopsy
• CD4 Lymphocyte Count
• Coinfection
• Doxorubicin (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• HIV Infections (complications, immunology, virology)
• Hepatitis E
• Humans
• Immunohistochemistry
• Lymphoma, Primary Effusion (complications, diagnosis, drug therapy, mortality)
• Male
• Middle Aged
• Polyethylene Glycols (administration & dosage, adverse effects, therapeutic use)
• Remission Induction
• Treatment Outcome