Abstract | OBJECTIVES: MATERIALS AND METHODS: In experiment 1, 30 male Sprague-Dawley rats were divided into 5 groups: (1) sham-operated; (2) hepatic ischemia-reperfusion injury; and (3-5) sodium nitrite administered intra-peritoneally 30 minutes before ischemia at 2.5, 25, and 250 μmol/kg, respectively. In experiment 2, 24 male Sprague-Dawley rats were divided into 4 groups: (1) hepatic ischemia-reperfusion injury; (2) sodium nitrite + hepatic ischemia-reperfusion injury; (3) C- PTIO + sodium nitrite + hepatic ischemia-reperfusion injury; and (4) allopurinol + sodium nitrite + hepatic ischemia-reperfusion injury. Sodium nitrite (25 μmol/kg) was then administered 30 minutes before hepatic ischemia, and C- PTIO or allopurinol was administered 5 minutes before sodium nitrite administration. Blood aspartate aminotransferase, alanine aminotransferase, hepatic tissue malondialdehyde, histologic changes, and expression of mitogen-activated protein kinase family members were evaluated. RESULTS: CONCLUSIONS:
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Authors | Eun Kyung Choi, Hoon Jung, Kyung-Ju Kim, So Jeong Kang, Hyun Jeong Kim, Jung A Lim, Kyung Hwa Kwak, Dong Gun Lim |
Journal | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
(Exp Clin Transplant)
Vol. 17
Issue 3
Pg. 348-354
(06 2019)
ISSN: 2146-8427 [Electronic] Turkey |
PMID | 30602366
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Xanthine Dehydrogenase
- Sodium Nitrite
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Topics |
- Animals
- Liver
(blood supply)
- Male
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(drug therapy)
- Sodium Nitrite
(metabolism, therapeutic use)
- Xanthine Dehydrogenase
(physiology)
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