Abstract | BACKGROUND: METHODS: Because yaws transmission is mainly due to direct skin contact with an infectious skin lesion, we evaluated the treponemicidal activity of GaM applied topically to skin lesions in a rabbit model of yaws. Treatment efficacy was evaluated by measuring lesion diameter, treponemal burden in lesion aspirates as determined by dark field microscopy and amplification of treponemal RNA, serology, and immunohistochemistry of biopsied tissue samples. RESULTS: Our results show that topical GaM was effective in reducing treponemal burden in yaws experimental lesions, particularly when applied at the first sign of lesion appearance but, as expected, did not prevent pathogen dissemination. CONCLUSION: Early administration of GaM to yaws lesions could reduce the infectivity of the lesions and thus yaws transmission, potentially contributing to current and future yaws control campaigns.
|
Authors | Lorenzo Giacani, Lawrence R Bernstein, Austin M Haynes, B Charmie Godornes, Giulia Ciccarese, Francesco Drago, Aurora Parodi, Sefora Valdevit, Luca Anselmi, Carlo Francesco Tomasini, Arthur M Baca |
Journal | PLoS neglected tropical diseases
(PLoS Negl Trop Dis)
Vol. 13
Issue 1
Pg. e0007076
(01 2019)
ISSN: 1935-2735 [Electronic] United States |
PMID | 30601824
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anti-Infective Agents, Local
- Organometallic Compounds
- Pyrones
- gallium maltolate
|
Topics |
- Animals
- Anti-Infective Agents, Local
(administration & dosage)
- Bacterial Load
- Disease Models, Animal
- Male
- Organometallic Compounds
(administration & dosage)
- Pyrones
(administration & dosage)
- Rabbits
- Skin
(microbiology, pathology)
- Treatment Outcome
- Treponema pallidum
(drug effects, isolation & purification)
- Yaws
(drug therapy, microbiology, pathology)
|