Amphotericin B deoxycholate for relapse visceral leishmaniasis in Bangladesh: a cross-sectional study.

Abstract

OBJECTIVE:

Based on studies in India (as there was no studies from outside India) amphotericin B deoxycholate has been considered as a backup drug for treatment of visceral leishmaniasis. However, treatment response and adverse effect to anti-leishmanial drugs may vary across different populations and in Bangladesh the effect to amphotericin B deoxycholate for treatment of visceral leishmaniasis is still unknown. Therefore, there is a need to explore cure rate and adverse effects to amphotericin B deoxycholate to justify its use on visceral leishmaniasis patients in Bangladesh.

RESULT:

Here we report 34 visceral leishmaniasis patients who received treatment with amphotericin B deoxycholate in the Surya Kanta Kala-azar Research Centre from December 2011 to June 2015. The dose of the treatment was 1 mg/kg body weight for 15 days followed up until 12 months after treatment. Response to amphotericin B deoxycholate treatment was excellent as all 34 patients achieved a final cure. Hypokalaemia (47%), shivering (47%), vomiting (35%) and acidity (15%) were most common adverse events. However, we did not observe any serious adverse events. Amphotericin B deoxycholate for relapse visceral leishmaniasis was found to be highly effective and safe. Our study justified to include amphotericin B deoxycholate as a second line drug for visceral leishmaniasis in Bangladesh.

• Authors: Md Golam Hasnain, Proggananda Nath, Shomik Maruf, Shah Golam Nabi, A F M Akhtar Hossain, Be-Nazir Ahmed, Dinesh Mondal, Ariful Basher
• Journal: BMC research notes (BMC Res Notes) Vol. 11 Issue 1 Pg. 918 (Dec 22 2018) ISSN: 1756-0500 [Electronic] England
• PMID: 30577877 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• Drug Combinations
• Deoxycholic Acid
• Amphotericin B
• amphotericin B, deoxycholate drug combination

Topics

• Adolescent
• Adult
• Amphotericin B (administration & dosage, adverse effects, pharmacology)
• Anti-Infective Agents (administration & dosage, adverse effects, pharmacology)
• Bangladesh
• Child
• Cross-Sectional Studies
• Deoxycholic Acid (administration & dosage, adverse effects, pharmacology)
• Drug Combinations
• Female
• Humans
• Leishmaniasis, Visceral (drug therapy)
• Male
• Recurrence
• Treatment Outcome