Two-Faced Immunity? The Evidence for Antibody Enhancement of Malaria Transmission.

Abstract

Plasmodium gametocytes can induce an immune response in humans that interferes with the development of sexual-stage parasites in the mosquito gut. Many early studies of the sexual-stage immune response noted that mosquito infection could be enhanced as well as reduced by immune sera. For Plasmodium falciparum, these reports are scarce, and the phenomenon is generally regarded as a methodological artefact. Plasmodium transmission enhancement (TE) remains contentious, but the clinical development of transmission-blocking vaccines based on sexual-stage antigens requires that it is further studied. In this essay, we review the early literature on the sexual-stage immune response and transmission-modulating immunity. We discuss hypotheses for the mechanism of TE, suggest experiments to prove or disprove its existence, and discuss its possible implications.

• Authors: Will Stone, Teun Bousema, Robert Sauerwein, Chris Drakeley
• Journal: Trends in parasitology (Trends Parasitol) Vol. 35 Issue 2 Pg. 140-153 (02 2019) ISSN: 1471-5007 [Electronic] England
• PMID: 30573175 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2018. Published by Elsevier Ltd.

Chemical References

• Antibodies, Protozoan
• Malaria Vaccines

Topics

• Antibodies, Protozoan (immunology)
• Humans
• Immunity (immunology)
• Malaria (immunology, transmission)
• Malaria Vaccines
• Plasmodium falciparum (immunology)