Role of oxidative stress, infection and inflammation in male infertility.

Abstract

Oxidative stress (OS), defined as an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, has been linked to sperm damage and male infertility. There are many sources of OS and inflammation including varicocele, tobacco usage, alcohol, obesity/metabolic syndrome, leukocytospermia, sexually transmitted disease (i.e., Neisseria gonorrhoeae, Chlamydia trachomatis, Treponema pallidum), bacterial prostatitis, microorganism mutations leading to more OS, and viral infections (i.e., human immunodeficiency virus, hepatitis). This review is focusing on infection and inflammation-mediated OS, the inflammatory markers underlying pathology, clinical significance in male infertility, and a brief description of the recommended treatment modalities.

• Authors: Ashok Agarwal, Mohit Rana, Emily Qiu, Hashem AlBunni, Albert D Bui, Ralf Henkel
• Journal: Andrologia (Andrologia) Vol. 50 Issue 11 Pg. e13126 (Dec 2018) ISSN: 1439-0272 [Electronic] Germany
• PMID: 30569652 (Publication Type: Journal Article, Review)
• Copyright: © 2018 Blackwell Verlag GmbH.

Chemical References

• Anti-Bacterial Agents
• Antioxidants
• Reactive Oxygen Species

Topics

• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Antioxidants (therapeutic use)
• Fertility (drug effects, immunology)
• Humans
• Infertility, Male (drug therapy, immunology, microbiology, prevention & control)
• Male
• Oxidative Stress (drug effects, immunology)
• Prostatitis (complications, drug therapy, immunology, microbiology)
• Reactive Oxygen Species (metabolism)
• Sexually Transmitted Diseases (complications, drug therapy, immunology, microbiology)
• Treatment Outcome