Abstract | BACKGROUND:
Polycystic ovary syndrome (PCOS) is associated with reproductive and metabolic abnormalities. The aim of this study was to analyse risk of cardiovascular disease (CVD) in PCOS, to define individual risk factors and assess their ability to predict risk. METHODS: RESULTS: Significantly higher CVRS values (p<0.05) were found in obese PCOS women compared to normal weight control and normal weight PCOS groups. Anthropometric parameters, lipid status parameters and fibrinogen (p<0.001, p<0.01) were higher in women with higher CVRS. The most significant CVRS predictors in all PCOS women were SHBG, androstenedione, follicle-stimulating hormone (FSH) and dehydroepiandrosterone sulphate (DHEAS). ICO and all NAFLD indices exhibited significant positive correlation with CVRS and a model consisting of these indices provided good diagnostic accuracy (AUC>0.8) in identifying patients with increased cardiovascular risk (CVR). CONCLUSIONS:
Obesity is a higher risk for developing CVD than PCOS alone. Anthropometric parameters, lipid parameters, fibrinogen, NAFLD indices and ICO increase CVR in PCOS women. For the prediction of CVR in PCOS, we suggest a combination of NAFLD indices and ICO.
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Authors | Iva Perovic Blagojevic, Tatjana Eror, Jovana Pelivanovic, Svetlana Jelic, Jelena Kotur-Stevuljevic, Svetlana Ignjatovic |
Journal | Journal of medical biochemistry
(J Med Biochem)
Vol. 36
Issue 3
Pg. 259-269
(Sep 2017)
ISSN: 1452-8258 [Print] Serbia |
PMID | 30568543
(Publication Type: Journal Article)
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